PWS growth charts during Growth Hormone treatment

0-36 MONTHS

To generate and report standardized growth curves for weight, length, head circumference, weight/length, and BMI for non– growth hormone–treated white infants (boys and girls) with PraderWilli syndrome (PWS) between 0 and 36 months of age. The goal was to monitor growth and compare data with other infants with PWS.

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0-18 YEARS

The purpose of the current study was to develop syndrome-specific standardized growth curves for growth hormone–treated Prader-Willi syndrome (PWS) individuals aged 0 to 18 years. Anthropometric growth-related measures were obtained on 171 subjects with PWS who were treated with growth hormone for at least 40% of their lifespan. They had no history of scoliosis. PWS standardized growth curves were developed for 7 percentile ranges using the LMS method for weight, height, head circumference, weight/length, and BMI along with normative 3rd, 50th, and 97th percentiles plotted using control data from the literature and growth databases. Percentiles were plotted on growth charts for comparison purposes. Growth hormone treatment appears to normalize stature and markedly improves weight in PWS compared with standardized curves for non–growth hormone–treated PWS individuals. Growth chart implications and recommended usage are discussed.

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3-18 YEARS NON-GROWTH HORMONE TREATED

The goal of this study was to generate and report standardized growth curves for abstract weight, height, head circumference, and BMI for non–growth hormone–treated white male and female US subjects with Prader-Willi syndrome (PWS) between 3 and 18 years of age and develop standardized growth charts.

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CB2 8AH. UK

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